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Since 1868, following the Laws of Suppression of Church property and on the basis of the subsequent 3 September Convention between the City of Florence and the Rector of Churches, the Community of the Dominican Fathers has held responsibility for the maintenance and all officiating duties of the Church buildings, including the liturgical and pastoral services, of the Basilica of Santa Maria Novella.

In 2001, following extensive restoration work to the Basilica of Santa Maria Novella, funded entirely by the Italian State for the grand 2000 Jubilee, the non-profit association Opera per Santa Maria Novella was founded on the the initiative of the monastery's Dominican Community. From its establishment the Opera agreed a Convention for the management and upgrading of the Santa Maria Novella complex’s heritage with the aim of improving the physical conservation of the artistic treasures kept there, cultural promotion and its maintenance as a place of worship.

On 24 December 2008, the Interior Ministry Fund for Places of Worship revoked the Basilica’s use by the City of Florence granting free use of the sacristy and crypt, with restricted control, as well as furnishings, bibliographic, archival and archaeological contents therein, to the Provincia Romana dei Frati Predicatori (‘Roman Province of the Friars Preachers’), the Dominicans.

Bearing this in mind, the Church remains principally a house of prayer and for that reason continues to guarantee free access to the Cappella della Pura (‘The Pura Chapel’) for worship and prayer. Tourist visits to the Basilica are limited on the basis of liturgical services and by the requirements of pastoral work.